Abstract: Taking the intelligent manufacturing cell platform as the research object, the design scheme of the platform simulation system is introduced in this paper. Firstly, the 3D modeling software UG is used to build the 3D models of each unit of the platform, which are imported into the ABB robot simulation software RobotStudio, and the layout of the intelligent manufacturing cell simulation platform is designed. Secondly, in order to realize the simulation process of product intelligent manufacturing, the Smart dynamic components are designed, the I/O signals of simulation communication, workstation logic and collision monitoring are set, and robot offline programming and simulation debugging are carried out. Finally, in order to simulate the joint debugging of robot and PLC, the Ethernet communication between RobotStudio software and TIA PORTAL software is created, and the control process equivalent to the operation of real equipment is realized, which is verified by the intelligent manufacturing unit experimental platform. The design scheme can provide theoretical basis for the simulation design and application implementation of intelligent manufacturing production line; and it also has reference significance for teaching of the intelligent manufacturing related courses in vocational colleges.