Abstract: As the core equipment of the intensive storage system, the shuttle vehicle needs the guide wheel to assist orientation in addition to the power provided by the shuttle vehicle traveling system when it travels on the three-dimensional shelf guide rail. In this paper, the technical characteristics of different guiding schemes of the guide wheel are studied in depth, the stress of the guide wheel is analyzed and discussed, and the force calculation and selection basis of guide wheel structure are proposed, the main structure size of guide wheel can be determined by calculating the horizontal lateral load of guide wheel deflection operation. Finally, an improved guide structure of shuttle vehicle is introduced. The test results show that the improved structure has obvious advantages, which can improve the service life of guide wheel and reduce the use cost, and provide a design reference for the improvement and optimization of shuttle vehicle structure design.