Abstract: In view of the poor transportation environment of Qilian Mountains's iron ore mines, as well as the backward transportation equipment and low transportation efficiency, and combining with the application of industrial Internet and unmanned driving technology in the complex environment of underground track of electric locomotive, an automatic unmanned driving system based on the integration of wired backbone network and wireless network, the optimized PLC interlock control system, the remote monitoring system, the safety protection system and the power supply measurement and control system is proposed in this paper. Focusing on the design and application of electric locomotive network communication system, automatic control operation system and operation status monitoring system, through application of the automatic unmanned electric locomotive transportation system, it is verified that the unmanned electric locomotive system can realize the safe and orderly dispatch and transportation of multiple underground electric locomotives, the automatic control operation, real-time monitoring and display the operating status parameters of the electric locomotive and the position information. The transportation efficiency is improved, the operation and maintenance time and costs are reduced, labor costs are saved, and production efficiency and security of the enterprises are significantly improved.