Abstract: In order to improve the heat transfer performance of nuclear waste concentrator, the application of spiral plate heat exchanger with perforated spoiler in nuclear waste liquid concentration is studied. With the use of periodic flow model in numerical simulation, the effect of different structural parameters of perforated spoilers on the flow resistance and heat transfer performance of heat exchanger is analyzed. The results show that increasing the length of the spoiler or decreasing the spacing will enhance the heat transfer performance in the flow channel. The comprehensive performance of the enhanced heat transfer of the perforated spoiler is less affected by the change of the spoiler length, and the spacing of the spoiler has great influence on the overall performance. The large-hole structure will reduce the pressure drop and heat transfer coefficient, while the overall heat transfer performance is higher. Under the conditions of film length of 60 mm, spacing of 100 mm and opening diameter of 13 mm, the comprehensive performance evaluation coefficient is the maximum value E=0.89 when the Re number is 33 238, and the comprehensive performance of the unopened spoiler is better when Re is greater than 49 858.