Abstract: The submicron particulate matter aerosol separator is a prerequisite for realizing the high-precision detection of particulate matter concentration, which is one of the current research hotspots. However, the current particulate aerosol separator still has more problems, the measurement distance is close in small flow rate, and the separation is not accurate in large flow rate. In this paper, a new type of high-flow submicron particulate aerosol precision separator is designed to realize the high-flow enrichment and precise separation of submicron particulate matter at remote monitoring points. Based on the principle of artificial tornado suction and Marple theory, the preliminary design of the model is carried out and the numerical analysis and numerical simulation are performed, and the SIMPLE algorithm is used to solve the pressure-velocity coupling. The particulate aerosol separator described in this paper balances the contradiction between the working flow rate and the cutting particle size, and analyzes and optimizes the structure, which greatly improves the performance of the new separator. Ultimately, it can accurately separate particles with a particle size of 0.1 μm under the high-flow conditions of 700 L/min and above.