Abstract: In this paper, a three-dimensional milling model is built based on the AdvantEdge metal cutting finite element simulation software. Through designing a three-level four-factor orthogonal experiment scheme, milling simulation machining for the titanium alloy material Ti6Al4V is conducted by using K series cemented carbide overall cylindrical milling cutter; and the contact surface stress time course curves of different tool geometry parameters under set machining conditions are obtained. By means of the comprehensive equilibrium method, the primary and secondary influence of tool geometry parameters on milling force and tool cutting temperature under multi-factor conditions is analyzed, and the optimal milling scheme is initially selected. Finally, the optimal scheme is verified by the method of variance analysis, and the effect of tool factors on the milling force and cutting temperature under a single change is analyzed respectively.