Abstract: The interventional therapy has become the primary measure in the treatment of cardiovascular diseases, but the current vascular stents still suffer from poor radial support performance and pliability. By analyzing and studying the structure of coronary vascular stents, four new Ni-Ti alloy vascular stents with different structural types, WS, WC, WM and VU were designed in this paper, and the radial support performance of the designed stents, the suppleness performance, and the geometrical parameter to the radial support performance of the WM stents were simulated and analyzed by using the finite element analysis method. The results show that the WM type stent has the largest radial support force, the smallest stress value, and the smallest bending stiffness, which is structurally optimal; as the stent thickness, the number of circumferential units, and the initial diameter increase, the radial support performance becomes better, but the same will bring disadvantages such as poorer suppleness, stent self-contact, and damage to the blood vessels. This study provides a reference for the design of novel vascular stent structures, which is of positive significance for promoting the treatment of cardiovascular diseases.