Abstract: Aiming at the problems of battery short-circuit tripping and explosion caused by the leakage of liquid-cooled energy storage internal cooling pipeline system, this paper analyzes the risk leakage points based on the pipeline assembly modeling and the established joint sealing form and connection scheme. Combined with the key factors that may trigger the failure of risk leakage points in the whole life cycle process of pipeline assembly production, assembly, transportation, operation and maintenance, the reliability evaluation method of pipeline assembly seal is inversely inferred based on the potential failure results. The test items, test purposes, test conditions, test methods and test criteria are designed from the aspects of material properties, pipeline sealing and pressure resistance, joint connection reliability, pipeline assembly life, vibration simulation and assembly convenience, and the key tests are supported. In the experiment, increasing the pressure of internal filling medium until the pipeline assembly is damaged, as well as multiple sets of engineering practice applications, the failure location is consistent with the inferred risk leakage point, reflecting the rationality of this reliability evaluation method and laying the foundation for the safe operation of liquid-cooled energy storage products.