Abstract: Taking the power end casing of F-2200HL mud pump as the research object, the luggage case of the casing is optimized. Through analysis and theoretical calculation of the load on the casing, the finite element model of the casing is established by SolidWorks software. Finally, the statics analysis of the casing model is carried out by using the Simulation finite element analysis module of SolidWorks software, then the stress and deformation of the casing are obtained. By comparing and analyzing the mechanical properties with the casing material, the reliability of the casing optimization design of F-2200HL mud pump is obtained and verified, which provides a reference for the optimization and improvement of other types of three-cylinder single-acting mud pumps.