Abstract: The frame development of electric two-wheelers is the primary step in the overall vehicle research and development, and it is also an important structure related to the comfort and strength of the vehicle. The evaluation research of the frame is an effective means to improve the user experience and vehicle performance. Through expert interviews, literature research and other methods, this study constructed a comprehensive evaluation system for the frame scheme, which includes product strategic compliance, technical performance, economy and production feasibility. The Analytic Hierarchy Process (AHP) was used to determine the index weights, and then the TOPSIS method was applied to rank the frame schemes in terms of superiority and inferiority. The feasibility of theoretical application was verified by taking the selection of three types of vehicle frames in actual projects as examples. This research not only provides reusable R&D decision-making tools for electric two-wheeler companies, but also offers theoretical references and practical examples for the industry to enhance the scientific and refined level of R&D management.