Abstract: To address the issue of abnormal rotation of the azimuth and pitch axes of the airborne electro-optical equipment during unmanned aerial vehicle （UAV） flight, this paper conducts a structural optimization design of the airborne electro-optical equipment based on wind resistance. By using CFD simulation technology, the pressure distribution and wind resistance moment of the equipment at different azimuth and pitch angles before optimization are calculated. The pressure distribution concentration at the side cover and pitch seat of the equipment and the variation law and maximum value of the wind resistance moment under these conditions are obtained. The side cover and pitch seat of the equipment are structurally optimized, and the wind resistance moment of the equipment after optimization is calculated. By comparing the calculation results, it is concluded that this structural optimization design can effectively reduce the wind resistance moment borne by the equipment, meeting the requirements for normal operation during UAV flight.