Abstract: To address the issue that the azimuth and pitch axes of airborne electro-optical equipment cannot rotate normally during UAV flight, this paper presents a structural optimization design for the equipment based on wind resistance. First, CFD simulation is employed to calculate the pressure distribution and wind resistance moment of the original equipment under different azimuth and pitch angles, so as to obtain the pressure concentration characteristics at the side cover and pitch mount, as well as the variation law and maximum value of wind resistance moment under such conditions. Then, structural optimization is carried out for the side cover and pitch mount, and the wind resistance moment of the optimized structure is computed.Comparison results show that the proposed structural optimization can effectively reduce the wind resistance moment exerted on the equipment, enabling it to meet the operational requirements during UAV flight.