Abstract: Against the backdrop of vocational education industry education integration and the development of intelligent manufacturing, this article relies on the Chinese characteristic apprenticeship system and focuses on the course of “Digital Design and Simulation of Intelligent Production Lines”, using the design of an automatic labeling station production line as a case study to carry out reform practices. Based on NX software for digital modeling of production lines, utilizing NX MCD platform combined with digital twin technology to complete mechanical and electrical conceptual design, collaborating with TIA Portal and PLCSIM Advanced to achieve virtual debugging, and building a full lifecycle digital management system. Practice has shown that the collaboration between school and enterprise mentors, engineering alternation, and project-based teaching models have improved students' technical application abilities and promoted the integration of theory and practice. This reform provides innovative solutions and theoretical references for talent cultivation in intelligent production lines and the intelligent transformation of manufacturing industry.